Fewer animal experiments due to optimal animal model selection
At the German Centre for the Protection of Laboratory Animals (Bf3R), these genome data were therefore studied again using the gene set enrichment analysis (GSEA) method.
The analysis of the BfR showed that in case of inflammations the reactions of some mouse models correlated very well with the data collected for humans. However, this did not apply to other mouse models. Such a data analysis is thus suitable for choosing the most appropriate animal model for the question to be investigated.
The article has been published in the international scientific journal “EMBO Molecular Medicine”.
Defining the optimal animal model for translational research using gene set enrichment analysis
Christopher Weidner, Matthias Steinfath, Elisa Opitz, Michael Oelgeschläger, Gilbert Schönfelder
DOI 10.15252/emmm.201506025, publiziert online 16.06.2016 EMBO Molecular Medicine (2016)