Kinetics of 15 per- and polyfluoroalkyl substances (PFAS) after single oral application as a mixture – A pilot investigation in a male volunteer

To get better data on kinetics of PFAS, a healthy volunteer orally ingested a mixture of fifteen predominantly 13C-labeled PFAS (“MPFAS”) in a pilot investigation.

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants with half-lives in humans in the range of years in case of the long-chain compounds, leading to accumulation and measurable levels in plasma. In contrast, short-chain and “alternative” PFAS have lower levels or are not detectable in humans with background exposure. This may be due to lower exposure, but also due to much shorter half-lives compared to long-chain compounds.

Data analysis revealed volumes of distribution between 110 and 177?mL/kg bw for most compounds. Half-lives were found to vary extremely, from 0.5?days and 1.5?days to 51?days and 152?days in case of the short-chain and “alternative” compounds. For the long-chain compounds, half-lives in the range of several years were confirmed. Overall, elimination kinetics seem to be determined by several different renal and gastrointestinal.

The article was published in the journal Environment International.

Kinetics of 15 per- and polyfluoroalkyl substances (PFAS) after single oral application as a mixture – A pilot investigation in a male volunteer

Klaus Abraham, Helena Mertens, Lennart Richter, Hans Mielke, Tanja Schwerdtle, Bernhard H. Monien

Environment International

2024, 109047